Iovance Biotherapeutics IncIovance Biotherapeutics Inc
Iovance Biotherapeutics Inc

Iovance Biotherapeutics Inc

IOVA
Health Care·Biotechnology

Iovance Biotherapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of cell therapies as novel cancer immunotherapy products. Its lead product candidate, LN-144 for metastatic melanoma, is an autologous adoptive cell therapy utilizing tumor-infiltrating lymphocytes (TIL), which are T cells derived from patients' tumors. The company was founded by Robert T. Brooke on September 17, 2007 and is headquartered in San Carlos, CA.

California; U.S.A
Market cap
No dataNo data
Revenue
$263.5M+60.6% YoY
Net income
$-391M−5.1% YoY
Free cash flow
$-336.2M+7.6% YoY

Market

Listed stock
IOVAPriceNasdaq
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Financial performance

Revenue
$263.5M+60.6% YoY
Operating income
$-403.4M−2.0% YoY
Net income
$-391M−5.1% YoY
Free cash flow
$-336.2M+7.6% YoY

Revenue, profit & cash trend

Revenue
Reference
Revenue: 2023 $1.2M, 2024 $164.1M, 2025 $263.5M. Reference line: Reference at $0.

Growth & profitability

Revenue growth
60.6%−1363839 bps YoY
Gross margin
No dataNo data
Operating margin
No dataNo data
FCF margin
No dataNo data

Earnings power over time

Operating income
Net income
Free cash flow
Operating income: 2021-12-31 $-342.7M, 2022-12-31 $-398.9M, 2023-12-31 $-460.6M, 2024-12-31 $-395.3M, 2025-12-31 $-403.4M. Net income: 2021-12-31 $-342.3M, 2022-12-31 $-395.9M, 2023-12-31 $-444M, 2024-12-31 $-372.2M, 2025-12-31 $-391M. Free cash flow: 2021-12-31 $-265.5M, 2022-12-31 $-313.2M, 2023-12-31 $-384.1M, 2024-12-31 $-364M, 2025-12-31 $-336.2M

Growth heatmap

20242025CAGR
Revenue
+13699.0%
+60.6%
+1385.8%
Gross profit
+518.9%
+125.4%
No data
Operating income
-16.4%
-15.5%
+14.2%
-2.0%
No data
Free cash flow
-18.0%
-22.6%
+5.2%
+7.6%
No data

Earnings quality

Operating cash flow
$-302.4M+14.3% YoY
Net income
$-391M−5.1% YoY
Free cash flow
$-336.2M+7.6% YoY
Diluted EPS
No dataNo data

Cash conversion quality

Operating cash flow
Free cash flow
Net income = 100%
Operating cash flow: 2025-12-31 77%, 2024-12-31 95%, 2023-12-31 81%, 2022-12-31 74%, 2021-12-31 67%. Free cash flow: 2025-12-31 86%, 2024-12-31 98%, 2023-12-31 87%, 2022-12-31 79%, 2021-12-31 78%. Reference line: Net income = 100% at 100%.

Per-share economics

Diluted EPS
Latest
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FCF / share
Latest
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Diluted shares
Latest
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Financial flexibility

Cash & equivalents
No dataNo data
Total debt
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Net debt
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Current ratio
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Cash Coverage of Debt

Cash / Total debt
No data

Returns

Return on equity
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Return on assets
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Return on invested capital
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Asset turnover
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Return on capital

No data

Valuation

Price to earnings
No dataNo data
Price to sales
No dataNo data
EV / EBITDA
No dataNo data
Free cash flow yield
No dataNo data

Valuation vs its own 5Y history

Metric
Own five-year range
Current
Own 5Y median
Position in own range
Price to earnings
No data
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Price to sales
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EV / EBITDA
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Free cash flow yield
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